NAD+ in Research: Understanding Cellular Energy and Longevity Signalling

NAD+ in Research: Understanding Cellular Energy and Longevity Signalling

Nicotinamide Adenine Dinucleotide (NAD+) is one of the most studied molecules in longevity and metabolic research. As a critical coenzyme in cellular redox reactions and a substrate for key signalling enzymes, it sits at the intersection of metabolism and aging biology.

NAD+ as a Redox Coenzyme

In its oxidised form (NAD+) and reduced form (NADH), this coenzyme participates in hundreds of metabolic reactions, particularly those involved in the citric acid cycle and oxidative phosphorylation. Declining NAD+ levels are consistently observed with aging.

NAD+ and Sirtuins

Sirtuins (SIRT1-7) are NAD+-dependent deacylases that regulate gene expression, DNA repair, and metabolic homeostasis. David Sinclair's research has highlighted the critical role of NAD+ availability in sirtuin function and its implications for aging research.